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Astrocytes Derived from Patients with Bipolar Disorder Malfunction – UC San Diego Health

A study by researchers from the Salk Institute and UC San Diego opens a potential new avenue for clinical intervention in a psychiatric disease.

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Brain cells called astrocytes derived from the induced pluripotent stem cells of patients with bipolar disorder offer suboptimal support for neuronal activity. In a paper in the journal Stem Cell Reports, researchers show thatthis malfunction can be traced to an inflammation-promoting molecule called interleukin-6 (IL-6), which is secreted by astrocytes. The results highlight the potential role of astrocyte-mediated inflammatory signaling in the psychiatric disease, although further investigation…

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